In a large skillet, cook ground beef and onion over medium heat until the meat is browned. Drain meat of any excess grease after cooking.
Add the salt, pepper, Italian seasoning, parsley, garlic powder, Worcestershire sauce, tomato paste, tomato sauce, sugar, and water. (If using store-bought marinara sauce, skip this step and add the jar of sauce to the ground beef and onion mixture)
Stir mozzarella cheese, cottage cheese, and Parmesan cheese together in a large bowl. Set aside.
If desired, prepare slow cooker by using a slow cooker liner.
Spoon a layer of the meat sauce onto the bottom of a slow cooker. Add a layer of uncooked lasagna noodles, breaking noodles to fit into cooker as needed. Top noodles with a portion of cheese mixture. Repeat the layering of sauce, noodles, and cheese two times. End with red pasta sauce as the final layer, and sprinkle more cheese all over the top.
Cook on LOW in the slow cooker for 4-5 hours or until the noodles are tender.